Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium

Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium

Alteration of action potential duration (APD) heterogeneity contributes to arrhythmogenesis. Purkinje-muscle junctions (PMJs) present differential electrophysiological properties including longer APD. The goal of this study was to determine if Purkinje-related or myocardial focal activation modulate...

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Bibliographic Details
Main Authors: Marine E. Martinez, Richard D. Walton, Jason D. Bayer, Michel Haïssaguerre, Edward J. Vigmond, Mélèze Hocini, Olivier Bernus
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
transmural heterogeneity
activation sequence
Purkinje-muscle junction
repolarization
optical mapping
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00718/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00718/full

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