Glycyrrhizin mitigates inflammatory bone loss and promotes expression of senescence-protective sirtuins in an aging mouse model of periprosthetic osteolysis

Although periprosthetic osteolysis induced by wear debris particles is significantly elevated in senior (65+ years old) patients, most of the published pre-clinical studies were performed using young (less than three-month old) mice indicating the critical need to employ experimental models of parti...

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Bibliographic Details
Main Authors: Chiaki Yamada, Anny Ho, Juliet Akkaoui, Christopher Garcia, Carolina Duarte, Alexandru Movila
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
MIF
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221002882