A novel role for ABCA1-generated large pre-β migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion[S]

A novel role for ABCA1-generated large pre-β migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion[S]

In Tangier disease, absence of ATP binding cassette transporter A1 (ABCA1) results in reduced plasma HDL and elevated triglyceride (TG) levels. We hypothesized that hepatocyte ABCA1 regulates VLDL TG secretion through nascent HDL production. Silencing of ABCA1 expression in oleate-stimulated rat hep...

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Bibliographic Details
Main Authors: Soonkyu Chung, Abraham K. Gebre, Jeongmin Seo, Gregory S. Shelness, John S. Parks
Format: Article
Language:English
Published: Elsevier 2010-04-01
Series:Journal of Lipid Research
Subjects:
hepatic ATP binding cassette transporter A1
very low density lipoprotein TG secretion
PI3 kinase signaling
ABCA1 silencing
Tangier disease
VLDL assembly
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520304831

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http://www.sciencedirect.com/science/article/pii/S0022227520304831

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