Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis

Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis

Viral infections are associated with increased incidence of severe sepsis. Particularly during the early stages, type I interferons (IFNs) are known mediators of detrimental effects. However, the functional role of early interferon β (IFNβ) and its cellular source during sepsis in...

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Bibliographic Details
Main Authors: Magdalena Howe, Jens Bauer, Anja Schulze, Sonja Kropp, Richard M. Locksley, Judith Alferink, Heike Weighardt, Stefanie Scheu
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
sepsis
viral infection
type I interferons
interferon β
IL-12
dendritic cells
cytokine reporter mouse model
immunotherapy
Online Access:https://www.mdpi.com/1422-0067/20/18/4410

Internet

https://www.mdpi.com/1422-0067/20/18/4410

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