Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression

Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression

An aberrant regulation of lipid metabolism is involved in the pathogenesis and progression of cancer. Up-regulation of lipid biosynthesis enzymes, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN) and HMG-CoA reductase (HMGCR), has been reported in many cancers. Therefore, elucidati...

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Bibliographic Details
Main Authors: Jittima Tomacha, Hasaya Dokduang, Sureerat Padthaisong, Nisana Namwat, Poramate Klanrit, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Tueanjit Khampitak, Supinda Koonmee, Attapol Titapun, Apiwat Jarearnrat, Narong Khuntikeo, Watcharin Loilome
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
lipid metabolism1
acetyl-CoA carboxylase2
fatty acid synthase3
HMG-CoA reductase4
metabolomics5
cholangiocarcinoma6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.696961/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.696961/full

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