Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Abstract Objectives Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no approved therapies directly target this activated subset of macrophage...

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Bibliographic Details
Main Authors: Yingwen Hu, Bingbing Wang, Jiayin Shen, Stewart A. Low, Karson S. Putt, Hans W. M. Niessen, Eric L. Matteson, Linda Murphy, Clemens Ruppert, Gerrit Jansen, Stephen J. Oliver, Yang Feng, Dimiter S. Dimitrov, Cheryl Nickerson-Nutter, Philip S. Low
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Arthritis Research & Therapy
Subjects:
Folate receptor beta
Activated macrophages
Inflammatory disease
Autoimmune disease
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s13075-019-1912-0

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http://link.springer.com/article/10.1186/s13075-019-1912-0

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