Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging

Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is affected, such as Alzheimer´s disease. Radiotracers used in the imaging studies are present at very small, nanomolar, concentration, whereas in vitro...

Full description

Bibliographic Details
Main Authors: Renske M. Raaphorst, Heli Savolainen, Mariangela Cantore, Evita van de Steeg, Aren van Waarde, Nicola A. Colabufo, Philip H. Elsinga, Adriaan A. Lammertsma, Albert D. Windhorst, Gert Luurtsema
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Pharmaceuticals
Subjects:
apical and basolateral membrane
bidirectional transport
blood-brain barrier
calcein-AM
tritium labeling
Online Access:https://www.mdpi.com/1424-8247/10/3/76

Internet

https://www.mdpi.com/1424-8247/10/3/76

Similar Items