Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin

Human alveolar macrophages have exceptionally high capacity to convert cholesterol into 27-hydroxycholesterol and cholestenoic acid by the sterol 27-hydroxylase mechanism. It is shown here that the human lung has a higher content of 27-hydroxycholesterol relative to cholesterol than any other organ....

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Bibliographic Details
Main Authors: Amir Babiker, Olof Andersson, Dan Lindblom, Jan van der Linden, Björn Wiklund, Dieter Lütjohann, Ulf Diczfalusy, Ingemar Björkhem
Format: Article
Language:English
Published: Elsevier 1999-08-01
Series:Journal of Lipid Research
Subjects:
pulmonary cholesterol
cytochrome P-450
isotope dilution–mass spectrometry
27-hydroxycholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520333836

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http://www.sciencedirect.com/science/article/pii/S0022227520333836

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