DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted by antisense inhibitory oligonucleotides.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13980 |