Functional synergy between the Munc13 C-terminal C1 and C2 domains

Functional synergy between the Munc13 C-terminal C1 and C2 domains

Neurotransmitter release requires SNARE complexes to bring membranes together, NSF-SNAPs to recycle the SNAREs, Munc18-1 and Munc13s to orchestrate SNARE complex assembly, and Synaptotagmin-1 to trigger fast Ca2+-dependent membrane fusion. However, it is unclear whether Munc13s function upstream and...

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Bibliographic Details
Main Authors: Xiaoxia Liu, Alpay Burak Seven, Marcial Camacho, Victoria Esser, Junjie Xu, Thorsten Trimbuch, Bradley Quade, Lijing Su, Cong Ma, Christian Rosenmund, Josep Rizo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
neurotransmitter release
Munc13
Munc18
C2 domain
reconstitution
membrane fusion
Online Access:https://elifesciences.org/articles/13696

Internet

https://elifesciences.org/articles/13696

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