Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization

Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization

The 3-trifluoroacetyl–substituted 7-acetamido-2-aryl-5-bromoindoles 5a–h were prepared and evaluated for potential antigrowth effect in vitro against human lung cancer (A549) and cervical cancer (HeLa) cells and for the potential to inhibit tubulin polymerization. The correspondi...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Nishal Parbhoo
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Pharmaceuticals
Subjects:
7-acetamido-2-aryl-5-bromoindoles
trifluoroacetylation
cytotoxicity
apoptosis
tubulin polymerization
molecular docking
Online Access:http://www.mdpi.com/1424-8247/11/2/59

Internet

http://www.mdpi.com/1424-8247/11/2/59

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