Optimization of a siRNA Carrier Modified with a pH-Sensitive Cationic Lipid and a Cyclic RGD Peptide for Efficiently Targeting Tumor Endothelial Cells

Optimization of a siRNA Carrier Modified with a pH-Sensitive Cationic Lipid and a Cyclic RGD Peptide for Efficiently Targeting Tumor Endothelial Cells

In recent years, anti-angiogenic therapy has attracted much interest because it is a versatile approach to treating most types of tumors, and therefore would be expected to be applicable for various cancers. Severe adverse events in patients treated with currently available anti-angiogenic therapeut...

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Bibliographic Details
Main Authors: Tomoya Hada, Yu Sakurai, Hideyoshi Harashima
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Pharmaceutics
Subjects:
siRNA delivery
tumor endothelial cells (TECs)
pH-sensitive carrier
cyclic RGD
post-modification method
Online Access:http://www.mdpi.com/1999-4923/7/3/320

Internet

http://www.mdpi.com/1999-4923/7/3/320

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