A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming.

A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming.

Cell specific states of the chromatin are programmed during mammalian development. Dynamic DNA methylation across the developing embryo guides a program of repression, switching off genes in most cell types. Thus, the majority of the tissue specific differentially methylated sites (TS-DMS) must be u...

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Bibliographic Details
Main Authors: Alejandro Colaneri, Tianyuan Wang, Vijayakanth Pagadala, Jaya Kittur, Nickolas G Staffa, Shyamal D Peddada, Elvira Isganaitis, Mary Elizabeth Patti, Lutz Birnbaumer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3771925?pdf=render

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http://europepmc.org/articles/PMC3771925?pdf=render

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