Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming.

Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming.

While reprogramming a foreign nucleus after somatic cell nuclear transfer (SCNT), the enucleated oocyte (ooplasm) must signal that biomass and cellular requirements changed compared to the nucleus donor cell. Using cells expressing nuclear-encoded but mitochondria-targeted EGFP, a strategy was devel...

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Bibliographic Details
Main Authors: Telma C Esteves, Olympia E Psathaki, Martin J Pfeiffer, Sebastian T Balbach, Dagmar Zeuschner, Hiroshi Shitara, Hiromichi Yonekawa, Marcin Siatkowski, Georg Fuellen, Michele Boiani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3367913?pdf=render

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http://europepmc.org/articles/PMC3367913?pdf=render

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