Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii; however, polymyxin resistance can emerge with monotherapy. Therefore, synergistic combination therapy is a crucial strategy to reduce polymyxin resistance.Methods: This study conducted un...

Full description

Bibliographic Details
Main Authors: Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Mengyao Li, Heidi H. Yu, Zhihui Zhou, Darren J. Creek, Jing Zhang, Jian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
polymyxin
beta-lactam
combination therapy
lipopolysaccharide
peptidoglycan
metabolomics
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02776/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02776/full

Similar Items