PDE2 Inhibits PKA-Mediated Phosphorylation of TFAM to Promote Mitochondrial Ca2+-Induced Colorectal Cancer Growth

PDE2 Inhibits PKA-Mediated Phosphorylation of TFAM to Promote Mitochondrial Ca2+-Induced Colorectal Cancer Growth

Growing evidence indicates that the dysregulation of mitochondrial calcium (Ca2+) plays a critical role in the growth of tumor cells, including colorectal cancer (CRC). However, the underling mechanism is not fully elucidated. In this study, the regulatory effects of mitochondrial Ca2+ on phosphodie...

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Bibliographic Details
Main Authors: Yilin Zhao, Yaya Wang, Jing Zhao, Zhaohui Zhang, Mingpeng Jin, Feng Zhou, Chao Jin, Jing Zhang, Jinliang Xing, Nan Wang, Xianli He, Tingting Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
mitochondrial Ca2+
colorectal cancer
mitochondrial transcription factor A
mitochondrial calcium uniporter
phosphodiesterase 2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.663778/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.663778/full

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