Implicating causal brain imaging endophenotypes in Alzheimer’s disease using multivariable IWAS and GWAS summary data

Implicating causal brain imaging endophenotypes in Alzheimer’s disease using multivariable IWAS and GWAS summary data

Recent evidence suggests the existence of many undiscovered heritable brain phenotypes involved in Alzheimer’s Disease (AD) pathogenesis. This finding necessitates methods for the discovery of causal brain changes in AD that integrate Magnetic Resonance Imaging measures and genotypic data. However,...

Full description

Bibliographic Details
Main Authors: Katherine A. Knutson, Yangqing Deng, Wei Pan
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:NeuroImage
Subjects:
Causal inference
Genetic pleiotropy
Instrumental variable
Mendelian randomization
MRI
MV-IWAS
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920308338

Internet

http://www.sciencedirect.com/science/article/pii/S1053811920308338

Similar Items