The large conductance Ca2+ -activated K+ (BKCa) channel regulates cell proliferation in SH-SY5Y neuroblastoma cells by activating the staurosporine-sensitive protein kinases

The large conductance Ca2+ -activated K+ (BKCa) channel regulates cell proliferation in SH-SY5Y neuroblastoma cells by activating the staurosporine-sensitive protein kinases

Here we investigated on the role of the calcium activated K+-channels(BKCa) on the regulation of the neuronal viability. Recordings of the K+-channel current were performed using patch-clamp technique in human neuroblastoma cells (SH-SY5Y) in parallel with measurements of the cell viability in the a...

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Bibliographic Details
Main Authors: Angela eCurci, Antonietta eMele, Giulia Maria eCamerino, Maria Maddalena eDinardo, Domenico eTricarico
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Physiology
Subjects:
Cell Proliferation
Staurosporine
maxi-calcium activated K+-channels
voltage dependent K+-channels
SH-SY5Y neuroblastoma cells
tyrosin kinases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00476/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00476/full

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