Genetic Alterations and Transcriptional Expression of m6A RNA Methylation Regulators Drive a Malignant Phenotype and Have Clinical Prognostic Impact in Hepatocellular Carcinoma

Genetic Alterations and Transcriptional Expression of m6A RNA Methylation Regulators Drive a Malignant Phenotype and Have Clinical Prognostic Impact in Hepatocellular Carcinoma

Background: N6-methyladenosine (m6A) RNA methylation, associated with cancer initiation and progression, is dynamically regulated by the m6A RNA regulators. However, its role in liver carcinogenesis is poorly understood.Methods: Three hundred seventy-one hepatocellular carcinoma (HCC) patients from...

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Bibliographic Details
Main Authors: Gui-Qi Zhu, Lei Yu, Yu-Jie Zhou, Jun-Xian Du, Shuang-Shuang Dong, Yi-Ming Wu, Ying-Hong Shi, Jian Zhou, Jia Fan, Zhi Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
RNA modification
m6A
hepatocellular carcinoma
TP53 mutation
prognosis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00900/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00900/full

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