Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

<p>Abstract</p> <p>Background</p> <p>The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlled by protein-protein int...

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Bibliographic Details
Main Authors: Valovka Taras, Hassa Paul O, Altmeyer Matthias, Haenni Sandra S, Fey Monika, Hottiger Michael O
Format: Article
Language:English
Published: BMC 2008-07-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/9/39