The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors

A novel series of 4-aryl-3-cyano-2-(3-hydroxyphenyl)-6-morpholino-pyridines have been designed as potential phosphatidylinositol-3-kinase (PI3K) inhibitors. The compounds have been synthesized using the Guareschi reaction to prepare the key 4-aryl-3-cyano-2,6-dihydroxypyridine intermediate. A differ...

Full description

Bibliographic Details
Main Authors: Ubaldina Galli, Elisa Ciraolo, Alberto Massarotti, Jean Piero Margaria, Giovanni Sorba, Emilio Hirsch, Gian Cesare Tron
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Molecules
Subjects:
PI3 kinase
pyridine
Guareschi reaction
isoforms
selectivity
Online Access:http://www.mdpi.com/1420-3049/20/9/17275

Internet

http://www.mdpi.com/1420-3049/20/9/17275

Similar Items