Overexpression of Hypoxia-Inducible Factor-1α Exacerbates Endothelial Barrier Dysfunction Induced by Hypoxia

Overexpression of Hypoxia-Inducible Factor-1α Exacerbates Endothelial Barrier Dysfunction Induced by Hypoxia

Background/Aims: The mechanisms involved in endothelial barrier dysfunction induced by hypoxia are incompletely understood. There is debate about the role of hypoxia-inducible factor-1α (HIF-1α) in endothelial barrier disruption. The aim of this study was to investigate the effect of genetic overexp...

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Bibliographic Details
Main Authors: Pei Wang, Huabing Qi, Chunhong Sun, Wen He, Gang Chen, Li Li, Fengjun Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hypoxia-inducible factor-1α
Hypoxia
Endothelial cell
Barrier dysfunction
ZO-1
Occludin
Myosin light chain kinase
Online Access:http://www.karger.com/Article/FullText/354488

Internet

http://www.karger.com/Article/FullText/354488

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