Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells.

Despite recent advances in the treatment of human colon cancer, the chemotherapy efficacy against colon cancer is still unsatisfactory. In the present study, effects of concomitant inhibition of the epidermal growth factor receptor (EGFR) and DNA methyltransferase were examined in human colon cancer...

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Bibliographic Details
Main Authors: Yun-feng Lou, Zheng-zhi Zou, Pin-jia Chen, Guo-bin Huang, Bin Li, De-qing Zheng, Xiu-rong Yu, Xiao-yong Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4038521?pdf=render