Hepatitis B Virus X Protein Increases 8-Oxo-7,8-Dihydro-2ʹ-Deoxyguanosine (8-Oxodg) Level via Repressing MTH1/ MTH2 Expression in Hepatocytes

Hepatitis B Virus X Protein Increases 8-Oxo-7,8-Dihydro-2ʹ-Deoxyguanosine (8-Oxodg) Level via Repressing MTH1/ MTH2 Expression in Hepatocytes

Background/Aims: Chronic hepatitis B virus (HBV) infection markedly increases the risk of development of hepatocellular carcinoma (HCC). Among the seven viral proteins that HBV encodes, HBV X protein (HBx) appears to have the most oncogenic potential. The mitochondria-associated HBx can induce oxida...

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Bibliographic Details
Main Authors: Yan-Ting Lin, Wei Liu, Yun He, Yun-Li Wu, Wan-Nan Chen, Xin-Jian Lin, Xu Lin
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hbv X protein
8-oxo-7
8-dihydro-2ʹ-deoxyguanosine
MTH1 (NUDT1)
MTH2 (NUDT15)
Online Access:https://www.karger.com/Article/FullText/495166

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https://www.karger.com/Article/FullText/495166

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