MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury

MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury

Abstract Background Spinal cord injury (SCI) has a very disabling central nervous system impact but currently lacks effective treatment. Bone marrow-derived macrophages (BMDMs) are recruited to the injured area after SCI and participate in the regulation of functional recovery with microglia. Previo...

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Bibliographic Details
Main Authors: Jiaxing Wang, Yuluo Rong, Chengyue Ji, Chengtang Lv, Dongdong Jiang, Xuhui Ge, Fangyi Gong, Pengyu Tang, Weihua Cai, Wei Liu, Jin Fan
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Nanobiotechnology
Subjects:
Autophagy
Bone marrow-derived macrophage
mTOR
Spinal cord injury
Small extracellular vesicle
Online Access:http://link.springer.com/article/10.1186/s12951-020-00630-5

Internet

http://link.springer.com/article/10.1186/s12951-020-00630-5

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