EGFR targeting of [177Lu] gold nanoparticles to colorectal and breast tumour cells: Affinity, duration of binding and growth inhibition of Cetuximab-resistant cells

EGFR targeting of [177Lu] gold nanoparticles to colorectal and breast tumour cells: Affinity, duration of binding and growth inhibition of Cetuximab-resistant cells

Objective: Radioimmunotherapy (RIT) is a systemic therapy currently used in the treatment of patients with lymphoma. RIT complexes consist of a targeting molecule, commonly an antibody, radionuclide chelates and a linker which can be a nanoparticle platform. Nanoparticles facilitate the attachment o...

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Bibliographic Details
Main Authors: Rekaya Shabbir, Marco Mingarelli, Gema Cabello, Marcel van Herk, Ananya Choudhury, Tim A.D. Smith
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of King Saud University: Science
Subjects:
Gold nanoparticles
EGFR
Cetuximab
Targeted radiotherapy
Xenografts
177Lu
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364721002354

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http://www.sciencedirect.com/science/article/pii/S1018364721002354

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