Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.

Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.

Genome wide association studies (GWAS) have established association of ARID5B and IKZF1 variants with childhood acute lymphoblastic leukemia (ALL). Epidemiological studies suggest that environmental factors alone appear to make a relatively minor contribution to disease risk. The polygenic nature of...

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Bibliographic Details
Main Authors: Tiffany-Jane Evans, Elizabeth Milne, Denise Anderson, Nicholas H de Klerk, Sarra E Jamieson, Bente A Talseth-Palmer, Nikola A Bowden, Elizabeth G Holliday, Jérémie Rudant, Laurent Orsi, Ebony Richardson, Laura Lavis, Daniel Catchpoole, John R Attia, Bruce K Armstrong, Jacqueline Clavel, Rodney J Scott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4195717?pdf=render

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http://europepmc.org/articles/PMC4195717?pdf=render

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