Alexander Disease Modeling in Zebrafish: An In Vivo System Suitable to Perform Drug Screening

Alexander Disease Modeling in Zebrafish: An In Vivo System Suitable to Perform Drug Screening

Alexander disease (AxD) is a rare astrogliopathy caused by heterozygous mutations, either inherited or arising de novo, on the glial fibrillary acid protein (GFAP) gene (17q21). Mutations in the GFAP gene make the protein prone to forming aggregates which, together with heat-shock protein 27 (HSP27)...

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Bibliographic Details
Main Authors: Simona Candiani, Silvia Carestiato, Andreas F. Mack, Daniele Bani, Matteo Bozzo, Valentina Obino, Michela Ori, Francesca Rosamilia, Miriam De Sarlo, Mario Pestarino, Isabella Ceccherini, Tiziana Bachetti
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Genes
Subjects:
Alexander disease
glial fibrillary acid protein
zebrafish
microinjection
Online Access:https://www.mdpi.com/2073-4425/11/12/1490

Internet

https://www.mdpi.com/2073-4425/11/12/1490

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