Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils.

Bibliographic Details
Main Authors: Luca Ferrari, Riccardo Stucchi, Katerina Konstantoulea, Gerarda van de Kamp, Renate Kos, Willie J. C. Geerts, Laura S. van Bezouwen, Friedrich G. Förster, Maarten Altelaar, Casper C. Hoogenraad, Stefan G. D. Rüdiger
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13745-7

Internet

https://doi.org/10.1038/s41467-019-13745-7

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