Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau
Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13745-7 |
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doaj-1e2a4433b35f46b3b264a6a1c10869f9 |
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Article |
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doaj-1e2a4433b35f46b3b264a6a1c10869f92021-05-11T09:20:20ZengNature Publishing GroupNature Communications2041-17232020-01-0111111310.1038/s41467-019-13745-7Arginine π-stacking drives binding to fibrils of the Alzheimer protein TauLuca Ferrari0Riccardo Stucchi1Katerina Konstantoulea2Gerarda van de Kamp3Renate Kos4Willie J. C. Geerts5Laura S. van Bezouwen6Friedrich G. Förster7Maarten Altelaar8Casper C. Hoogenraad9Stefan G. D. Rüdiger10Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht UniversityScience for Life, Utrecht UniversityCellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht UniversityCellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht UniversityCellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht UniversityScience for Life, Utrecht UniversityScience for Life, Utrecht UniversityScience for Life, Utrecht UniversityScience for Life, Utrecht UniversityScience for Life, Utrecht UniversityCellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht UniversityTau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils.https://doi.org/10.1038/s41467-019-13745-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Luca Ferrari Riccardo Stucchi Katerina Konstantoulea Gerarda van de Kamp Renate Kos Willie J. C. Geerts Laura S. van Bezouwen Friedrich G. Förster Maarten Altelaar Casper C. Hoogenraad Stefan G. D. Rüdiger |
| spellingShingle |
Luca Ferrari Riccardo Stucchi Katerina Konstantoulea Gerarda van de Kamp Renate Kos Willie J. C. Geerts Laura S. van Bezouwen Friedrich G. Förster Maarten Altelaar Casper C. Hoogenraad Stefan G. D. Rüdiger Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau Nature Communications |
| author_facet |
Luca Ferrari Riccardo Stucchi Katerina Konstantoulea Gerarda van de Kamp Renate Kos Willie J. C. Geerts Laura S. van Bezouwen Friedrich G. Förster Maarten Altelaar Casper C. Hoogenraad Stefan G. D. Rüdiger |
| author_sort |
Luca Ferrari |
| title |
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau |
| title_short |
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau |
| title_full |
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau |
| title_fullStr |
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau |
| title_full_unstemmed |
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau |
| title_sort |
arginine π-stacking drives binding to fibrils of the alzheimer protein tau |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils. |
| url |
https://doi.org/10.1038/s41467-019-13745-7 |
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