A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease.

A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease.

Chikungunya virus (CHIKV) is a re-emerging arbovirus responsible for a massive outbreak currently afflicting the Indian Ocean region and India. Infection from CHIKV typically induces a mild disease in humans, characterized by fever, myalgia, arthralgia, and rash. Cases of severe CHIKV infection invo...

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Bibliographic Details
Main Authors: Thérèse Couderc, Fabrice Chrétien, Clémentine Schilte, Olivier Disson, Madly Brigitte, Florence Guivel-Benhassine, Yasmina Touret, Georges Barau, Nadège Cayet, Isabelle Schuffenecker, Philippe Desprès, Fernando Arenzana-Seisdedos, Alain Michault, Matthew L Albert, Marc Lecuit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18282093/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18282093/pdf/?tool=EBI

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