Early Enzyme Replacement Therapy Improves Hearing and Immune Defects in Adenosine Deaminase Deficient-Mice

Early Enzyme Replacement Therapy Improves Hearing and Immune Defects in Adenosine Deaminase Deficient-Mice

Background: Inherited defects in adenosine deaminase (ADA) cause severe immune deficiency, which can be corrected by ADA enzyme replacement therapy (ERT). Additionally, ADA-deficient patients suffer from hearing impairment. We hypothesized that ADA-deficient (–/–) mice also exhibit hearing abnormali...

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Bibliographic Details
Main Authors: Xiaobai Xu, Jaina Negandhi, Weixian Min, Michael Tsui, Martin Post, Robert V. Harrison, Eyal Grunebaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
adenosine deaminase deficiency
hearing
enzyme replacement
PEG-ADA
enzyme replacement therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00416/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00416/full

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