Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

We report the novel crystal structure and characterization of symmetrical, homodimeric humanized heavy-chain-only antibodies or dimers (HC2s). HC2s were found to be significantly coexpressed and secreted along with mAbs from transient CHO HC/LC cotransfection, resulting in an unacceptable mAb develo...

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Bibliographic Details
Main Authors: Carl Mieczkowski, Soheila Bahmanjah, Yao Yu, Jeanne Baker, Gopalan Raghunathan, Daniela Tomazela, Mark Hsieh, Mark McCoy, Corey Strickland, Laurence Fayadat-Dilman
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antibodies
Subjects:
antibody
heavy-chain dimer
heavy-chain antibody
crystal structure
Online Access:https://www.mdpi.com/2073-4468/9/4/66

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https://www.mdpi.com/2073-4468/9/4/66

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