Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies
We report the novel crystal structure and characterization of symmetrical, homodimeric humanized heavy-chain-only antibodies or dimers (HC2s). HC2s were found to be significantly coexpressed and secreted along with mAbs from transient CHO HC/LC cotransfection, resulting in an unacceptable mAb develo...
Main Authors: | Carl Mieczkowski, Soheila Bahmanjah, Yao Yu, Jeanne Baker, Gopalan Raghunathan, Daniela Tomazela, Mark Hsieh, Mark McCoy, Corey Strickland, Laurence Fayadat-Dilman |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
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Series: | Antibodies |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4468/9/4/66 |
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