Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery.

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery.

INTRODUCTION:Exosome nanoparticles carry a composite cargo, including microRNAs (miRs). Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of miRNAs from the heart is largely unexplored. Working on clinical samples from coronary-artery by-pass graft (CABG) surger...

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Bibliographic Details
Main Authors: Costanza Emanueli, Andrew I U Shearn, Abas Laftah, Francesca Fiorentino, Barnaby C Reeves, Cristina Beltrami, Andrew Mumford, Aled Clayton, Mark Gurney, Saran Shantikumar, Gianni D Angelini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4851293?pdf=render

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http://europepmc.org/articles/PMC4851293?pdf=render

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