Impact of mutations in DNA methylation modification genes on genome-wide methylation landscapes and downstream gene activations in pan-cancer

Impact of mutations in DNA methylation modification genes on genome-wide methylation landscapes and downstream gene activations in pan-cancer

Abstract Background In cancer, mutations of DNA methylation modification genes have crucial roles for epigenetic modifications genome-wide, which lead to the activation or suppression of important genes including tumor suppressor genes. Mutations on the epigenetic modifiers could affect the enzyme a...

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Bibliographic Details
Main Authors: Chai-Jin Lee, Hongryul Ahn, Dabin Jeong, Minwoo Pak, Ji Hwan Moon, Sun Kim
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Medical Genomics
Subjects:
DNA methylation modifier
Sub-network clustering
DMR-DEG integration
Pan-cancer analysis
Genome-wide landscape
Online Access:http://link.springer.com/article/10.1186/s12920-020-0659-4

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http://link.springer.com/article/10.1186/s12920-020-0659-4

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