A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.

A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.

<h4>Background</h4>Studies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher grades of cervical intraepithelial neoplasia (CIN 2+). However, it is unknown whether exposure to higher folate...

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Bibliographic Details
Main Authors: Suguna Badiga, Gary L Johanning, Maurizio Macaluso, Andres Azuero, Michelle M Chambers, Nuzhat R Siddiqui, Chandrika J Piyathilake
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0110093

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https://doi.org/10.1371/journal.pone.0110093

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