MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State

MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State

Summary: Dynamic establishment of histone modifications in early development coincides with programed cell fate restriction and loss of totipotency beyond the early blastocyst stage. Causal function of histone-modifying enzymes in this process remains to be defined. Here we show that inhibiting hist...

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Bibliographic Details
Main Authors: Hui Zhang, Le Tran Phuc Khoa, Fengbiao Mao, Hanshi Xu, Bo Zhou, Yu Han, Monique O’Leary, Asma Nusrat, Li Wang, Thomas L. Saunders, Yali Dou
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719313968

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http://www.sciencedirect.com/science/article/pii/S2211124719313968

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