Irisin attenuates myocardial ischemia/reperfusion‐induced cardiac dysfunction by regulating ER‐mitochondria interaction through a mitochondrial ubiquitin ligase‐dependent mechanism

Irisin attenuates myocardial ischemia/reperfusion‐induced cardiac dysfunction by regulating ER‐mitochondria interaction through a mitochondrial ubiquitin ligase‐dependent mechanism

Abstract Background Myocardial ischemia/reperfusion (MI/R) injury imposes devastating cardiovascular sequelae in particular cardiac dysfunction as a result of restored blood flow. However, the mechanism behind MI/R injury remains elusive. Mitochondrial ubiquitin ligase (MITOL/MARCH5) is localized at...

Full description

Bibliographic Details
Main Authors: Linhe Lu, Jipeng Ma, Jiayou Tang, Yang Liu, Qijun Zheng, Shasha Chen, Erhe Gao, Jun Ren, Lifang Yang, Jian Yang
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Clinical and Translational Medicine
Subjects:
apoptosis
endoplasmic reticulum stress
irisin (FNDC5)
mitochondrial ubiquitin ligase (MITOL)
myocardial ischemia/reperfusion (MI/R)
reactive oxygen species (ROS)
Online Access:https://doi.org/10.1002/ctm2.166

Internet

https://doi.org/10.1002/ctm2.166

Similar Items