Non-canonical TAF complexes regulate active promoters in human embryonic stem cells

Non-canonical TAF complexes regulate active promoters in human embryonic stem cells

The general transcription factor TFIID comprises the TATA-box-binding protein (TBP) and approximately 14 TBP-associated factors (TAFs). Here we find, unexpectedly, that undifferentiated human embryonic stem cells (hESCs) contain only six TAFs (TAFs 2, 3, 5, 6, 7 and 11), whereas following differenti...

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Bibliographic Details
Main Authors: Glenn A Maston, Lihua Julie Zhu, Lynn Chamberlain, Ling Lin, Minggang Fang, Michael R Green
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2012-11-01
Series:eLife
Subjects:
transcription factor
TATA-box-binding protein
pre-initiation complex
human embryonic stem cell
TBP-associated factor
pluripotency gene expression
Online Access:https://elifesciences.org/articles/00068

Internet

https://elifesciences.org/articles/00068

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