Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Star...

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Bibliographic Details
Main Authors: Valentina Sepe, Francesco Saverio Di Leva, Claudio D'Amore, Carmen Festa, Simona De Marino, Barbara Renga, Maria Valeria D'Auria, Ettore Novellino, Vittorio Limongelli, Lisette D'Souza, Mahesh Majik, Angela Zampella, Stefano Fiorucci
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Marine Drugs
Subjects:
soft coral
Sinularia kavarattiensis
pregnane X receptor (PXR)
hydroxysteroids
docking simulations
Online Access:http://www.mdpi.com/1660-3397/12/6/3091

Internet

http://www.mdpi.com/1660-3397/12/6/3091

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