Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function

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Anucleate platelets circulate in the blood to facilitate thrombosis and diverse immune functions. Platelet activation leading to clot formation correlates with increased glycogenolysis, glucose uptake, glucose oxidation, and lactic acid production. Simultaneous deletion of glucose transporter (GLUT)...

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Bibliographic Details
Main Authors: Trevor P. Fidler, Robert A. Campbell, Trevor Funari, Nicholas Dunne, Enrique Balderas Angeles, Elizabeth A. Middleton, Dipayan Chaudhuri, Andrew S. Weyrch, E. Dale Abel
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
glucose
metabolism
glucose transporters
platelet
megakaryocyte
calpain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309312

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http://www.sciencedirect.com/science/article/pii/S2211124717309312

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