Reversible Neonatal Cholestasis Following In Utero Exposure to Valproic Acid

Valproic acid (VPA) is a branched-chain carboxylic acid with broad anticonvulsant activity. Its spectrum of activity is thought to be mediated by combined molecular effects on intercellular Na+ currents, neuron K+ channels, and inhibition of gamma-aminobutyric acid (GABA) transaminase (1,2). VPA is...

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Bibliographic Details
Main Authors: Douglas G Chang, Martin Stein, David Sine, David Yeung, Frank Mannino
Format: Article
Published: McGill University 2020-12-01
Series:McGill Journal of Medicine
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