Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

<p>Abstract</p> <p>Background</p> <p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium h...

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Bibliographic Details
Main Authors: Zippelius Annette, Ferri Alberto, Leutbecher Christine, Goos Miriam, Zech Wolf-Dieter, Jaiswal Manoj, Carrì Maria, Nau Roland, Keller Bernhard U
Format: Article
Language:English
Published: BMC 2009-06-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/10/64