Computational Drug Repurposing Algorithm Targeting TRPA1 Calcium Channel as a Potential Therapeutic Solution for Multiple Sclerosis

Computational Drug Repurposing Algorithm Targeting TRPA1 Calcium Channel as a Potential Therapeutic Solution for Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS) through neurodegeneration and demyelination, leading to physical/cognitive disability and neurological defects. A viable target for treating MS appears to be the Transient Receptor Potential Ankyrin 1...

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Bibliographic Details
Main Authors: Dragos Paul Mihai, George Mihai Nitulescu, George Nicolae Daniel Ion, Cosmin Ionut Ciotu, Cornel Chirita, Simona Negres
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceutics
Subjects:
transient receptor potential channels
QSAR
molecular docking
data mining
drug-repurposing
neurodegeneration
demyelination
antinociception
desvenlafaxine
paliperidone
febuxostat
Online Access:https://www.mdpi.com/1999-4923/11/9/446

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https://www.mdpi.com/1999-4923/11/9/446

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