Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration.

Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration.

Mitochondrial dysfunction is associated with the development and progression of age-related macular degeneration (AMD). Recent studies using populations from the United States and Australia have demonstrated that AMD is associated with mitochondrial (mt) DNA haplogroups (as defined by combinations o...

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Bibliographic Details
Main Authors: M Cristina Kenney, Marilyn Chwa, Shari R Atilano, Janelle M Pavlis, Payam Falatoonzadeh, Claudio Ramirez, Deepika Malik, Tiffany Hsu, Grace Woo, Kyaw Soe, Anthony B Nesburn, David S Boyer, Baruch D Kuppermann, S Michal Jazwinski, Michael V Miceli, Douglas C Wallace, Nitin Udar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3554762?pdf=render

Internet

http://europepmc.org/articles/PMC3554762?pdf=render

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