Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

The respiratory syncytial virus (RSV) fusion protein F is considered an attractive vaccine candidate especially in its prefusion conformation. We studied whether recombinant soluble RSV F proteins could be stabilized in a prefusion-like conformation by mutation of heptad repeat B (HRB). The results...

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Bibliographic Details
Main Authors: Ivy Widjaja, Alan Rigter, Shamir Jacobino, Frank J M van Kuppeveld, Kees Leenhouts, Concepción Palomo, Jose A Melero, Jeanette H W Leusen, Bert Jan Haijema, Peter J M Rottier, Cornelis A M de Haan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4481108?pdf=render

Internet

http://europepmc.org/articles/PMC4481108?pdf=render

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