Refined efficacy estimates of the Sanofi Pasteur dengue vaccine CYD-TDV using machine learning

Refined efficacy estimates of the Sanofi Pasteur dengue vaccine CYD-TDV using machine learning

Clinical trials for the CYD-TDV dengue vaccine showed that vaccine efficacy varies with prior dengue exposure, but baseline serostatus is only known for 12% of subjects. Here, Dorigatti et al. use machine learning to impute baseline serostatus and determine vaccine efficacy by baseline serostatus, a...

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Bibliographic Details
Main Authors: I. Dorigatti, C. A. Donnelly, D. J. Laydon, R. Small, N. Jackson, L. Coudeville, N. M. Ferguson
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06006-6

Internet

https://doi.org/10.1038/s41467-018-06006-6

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