Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolaemia: A Propensity Score Analysis

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolaemia: A Propensity Score Analysis

Background<b>: </b>The monogenic defect in familial hypercholesterolemia (FH) is detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C). We sought to investigate whether the underlying monogenic or polygenic defect is...

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Bibliographic Details
Main Authors: Agnieszka Mickiewicz, Marta Futema, Agnieszka Ćwiklinska, Agnieszka Kuchta, Maciej Jankowski, Mariusz Kaszubowski, Magdalena Chmara, Bartosz Wasąg, Marcin Fijałkowski, Miłosz Jaguszewski, Steve E. Humphries, Marcin Gruchała
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Life
Subjects:
polygenic hypercholesterolemia
monogenic hypercholesterolemia
rosuvastatin
propensity score
Online Access:https://www.mdpi.com/2075-1729/10/5/73

Internet

https://www.mdpi.com/2075-1729/10/5/73

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