Investigating effect of water of hydration on active pharmaceutical ingredients in a water-sensitive dosage form

Investigating effect of water of hydration on active pharmaceutical ingredients in a water-sensitive dosage form

Abstract Background Preparation of mini buccal tablets incorporating either of the Alzheimer’s drugs, rivastigmine tartrate or donepezil hydrochloride, were developed for patients who have difficulty swallowing as a source of effervescence, by pairing the less commonly used malic acid with sodium bi...

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Bibliographic Details
Main Authors: Monica C. Chuong, Charles J. Kelley, Yosra Muhammad, Thais Dias Caputo, Jader M. Gomes, Denise Oliveira, Andiara Cardoso Peixoto, Bruna Sanches Pereira, Waleed Rizg, Carolina Vazquez, Thiago Medeiros Zacaron, Steven Nguyen, David A. Williams
Format: Article
Language:English
Published: SpringerOpen 2018-02-01
Series:Journal of Analytical Science and Technology
Subjects:
Friability
Hardness
Differential scanning calorimetry
Donepezil HCl
Fourier-transform infrared spectroscopy
Malic acid
Online Access:http://link.springer.com/article/10.1186/s40543-018-0135-3

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http://link.springer.com/article/10.1186/s40543-018-0135-3

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